Supporting Information Title: Aggregation-triggering segments of SOD1 fibril formation support a common pathway for familial and sporadic ALS
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چکیده
Title: Aggregation-triggering segments of SOD1 fibril formation support a common pathway for familial and sporadic ALS Authors: Magdalena I Ivanova, Stuart A Sievers, Elizabeth L. Guenther, Lisa M. Johnson, Duane D. Winkler, Ahmad Galaleldeen, Michael R Sawaya, P. John Hart, David Eisenberg Corresponding author: Howard Hughes Medical Institute, UCLA-DOE Institute for Genomics and Proteomics, Department of Biological Chemistry, UCLA, Los Angeles CA 9095-1570 Email: [email protected] Phone: 310 825-3754
منابع مشابه
Aggregation-triggering segments of SOD1 fibril formation support a common pathway for familial and sporadic ALS.
ALS is a terminal disease of motor neurons that is characterized by accumulation of proteinaceous deposits in affected cells. Pathological deposition of mutated Cu/Zn superoxide dismutase (SOD1) accounts for ∼20% of the familial ALS (fALS) cases. However, understanding the molecular link between mutation and disease has been difficult, given that more than 140 different SOD1 mutants have been o...
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Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder that targets motor neurons, leading to paralysis and death within a few years of disease onset. While several genes have been linked to the inheritable, or familial, form of ALS, much less is known about the cause(s) of sporadic ALS, which accounts for ~90% of ALS cases. Due to the clinical similarities between familial a...
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